4-Nitrobenzoic acid

Common Name	4-Nitrobenzoic acid
CAS Number	62-23-7	Molecular Weight	167.119
Density	1.5±0.1 g/cm3	Boiling Point	359.1±25.0 °C at 760   mmHg
Molecular Formula	C7H5NO4	Melting Point	237-240 °C(lit.)
Structural formula		Flash Point	166.5±11.6 °C
Symbol	GHS07	Signal Word	Warning

CHEMICAL IDENTIFICATION

RTECS NUMBER :DH5075000

CHEMICAL NAME :Benzoic acid, p-nitro-

CAS REGISTRY NUMBER :62-23-7

LAST UPDATED :199701

DATA ITEMS CITED :26

MOLECULAR FORMULA :C7-H5-N-O4

MOLECULAR WEIGHT :167.13

WISWESSER LINE NOTATION :WNR DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :Standard Draize test

ROUTE OF EXPOSURE :Administration into the eye

SPECIES OBSERVED :Rodent - rabbit

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1960 mg/kg

TOXIC EFFECTS :Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1210 mg/kg

TOXIC EFFECTS :Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Parenteral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :1960 mg/kg

TOXIC EFFECTS :Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :880 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - aggression

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :770 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - aggression

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Parenteral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :1470 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - aggression

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :11760 mg/kg/14D-C

TOXIC EFFECTS :Blood - normocytic anemia Blood - methemoglobinemia-carboxyhemoglobin Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :10400 mg/kg/13W-C

TOXIC EFFECTS :Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :56 gm/kg/14D-C

TOXIC EFFECTS :Liver - changes in liver weight Endocrine - changes in thymus weight

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :11050 mg/kg/13W-C

TOXIC EFFECTS :Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :45063 mg/kg/2Y-C

TOXIC EFFECTS :Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :Sister chromatid exchange

TEST SYSTEM :Rodent - hamster Ovary

DOSE/DURATION :1 gm/L

REFERENCE :

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,269,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83217 No. of Facilities: 32 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 396 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83217 No. of Facilities: 3573 (estimated) No. of Industries: 31 No. of Occupations: 46 No. of Employees: 42700 (estimated) No. of Female Employees: 12407 (estimated)

Use 1: Used as a chemical reagent.

Use 2: It is used as a pharmaceutical intermediate, and it is also a raw material for the production of dyes.

Use 3: It is used for the preparation of anesthetic procaine hydrochloride and dye intermediates, as well as for the preparation of filters, and also for the production of photosensitive materials, the production of photosensitive materials and the electric paste in capacitors.

Use 4: It is used to synthesize procaine, procaine amide, p-aminobenzoic acid, folic acid, etc. It is also widely used to synthesize pesticides and fuels.

Use 5: Test alkaloids, standardize standard alkali solutions.