4-Aminobenzoic acid

Common Name	4-Aminobenzoic acid
CAS Number	150-13-0	Molecular Weight	137.136
Density	1.3±0.1 g/cm3	Boiling Point	339.9±25.0 °C at 760   mmHg
Molecular Formula	C7H7NO2	Melting Point	187-189 °C(lit.)
Structural formula		Flash Point	159.4±23.2 °C
Symbol	GHS07	Signal Word	Warning

CHEMICAL IDENTIFICATION

RTECS NUMBER :DG1400000

CHEMICAL NAME :Benzoic acid, p-amino-

CAS REGISTRY NUMBER :150-13-0

BEILSTEIN REFERENCE NO. :0471605

LAST UPDATED :199710

DATA ITEMS CITED :17

MOLECULAR FORMULA :C7-H7-N-O2

MOLECULAR WEIGHT :137.15

WISWESSER LINE NOTATION :ZR DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :>6 gm/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intraperitoneal

SPECIES OBSERVED :Rodent - rat

DOSE/DURATION :>3450 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - mouse

DOSE/DURATION :2850 mg/kg

TOXIC EFFECTS :Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Mammal - dog

DOSE/DURATION :1 gm/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :1830 mg/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :Intravenous

SPECIES OBSERVED :Rodent - rabbit

DOSE/DURATION :2 gm/kg

TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

SPECIES OBSERVED :Mammal - species unspecified

DOSE/DURATION :182 mg/kg/26W-I

TOXIC EFFECTS :Liver - other changes Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

TYPE OF TEST :TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :Oral

DOSE :2500 mg/kg

SEX/DURATION :female 1-22 day(s) after conception

TOXIC EFFECTS :Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TEST SYSTEM :Rodent - mouse

DOSE/DURATION :1 gm/kg

REFERENCE :ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 5,355,1982 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,249,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,249,1978 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80471 No. of Facilities: 144 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 8957 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80471 No. of Facilities: 821 (estimated) No. of Industries: 3 No. of Occupations: 21 No. of Employees: 10227 (estimated) No. of Female Employees: 6397 (estimated)

4-Aminobenzoic acid is an intermediate in the synthesis of folate by bacteria, plants, and fungi.